Objective: To determine the therapeutic efficacy and safety of plasmapheresis in the treatment of patients with severe sepsis and septic shock. <br>Design: Prospective, randomised, clinical trial with a planned, midstudy, interim analysis. <br>Setting: Intensive care unit in a university hospital in Archangels, Russia. <br>Patients: Consecutive patients with severe sepsis or septic shock. <br ...